If there are pickups or chests, the icons will flash every time you enter a room.
This can also enable you to locate the secret room.
It is a good idea to draw a copy of the map and make a note of things you cannot access immediately, such as locked item rooms or chests.
Ever since the Eternal Update The World or The Sun Tarot Cards and Crystal Ball will override the curse. Having the Treasure Map or The Compass will not override this curse. Removes the map, replacing it with a single black room with a question mark in the middle (same as the Devil Room) for the duration of that floor. (For example, The Caves affected by Curse Of The Lost would be as large as The Depths) Curse of the Lost increases the size of one "tier".